At present, only patients who are eligible for a clinical trial can have an islet transplant at University of Minnesota Medical Center. But for many of them, the procedure has been life-changing. Some have even been able to stop using insulin altogether for five years or longer.
If you have had type 1 diabetes for a number of years, you may lose the early symptoms of low blood glucose such as sweating, dizziness and extreme hunger that warn you that your blood glucose level is too low. This inability to sense a low blood glucose is called hypoglycemia unawareness. It raises the risk of severe hypoglycemia (blood glucose lows). When this occurs, you often need help from someone else to help you raise your blood glucose such as giving you juice, soda pop or a glucagon injection.
Currently, the only way to restore normal blood glucose levels in people with type 1 diabetes (without the risk of low blood sugar) is to replace their islets. Only a pancreas transplant or an islet transplant can replace the islets. If you experience severe hypoglycemia, you may be eligible to participate in an islet transplant clinical trial.
What are the benefits of islet transplantation?
Insulin therapy, whether by injection or insulin pump, is life-saving. However, insulin therapy is not perfect. Most people with type 1 diabetes still have blood glucose levels that are above normal, putting them at risk for long-term complications of diabetes. Patients able to keep their blood glucose levels near normal often have trouble with low blood glucose (hypoglycemia).
The possible advantage of islet transplantation over giving insulin via injections or pump is that the transplanted islets may maintain normal blood sugar under all conditions. Also, they would not produce excess insulin which can result in low blood glucose.
The goal of an islet transplant is the safe and effective treatment of type 1 diabetes. Although islet transplants have been performed in clinical trials for years, they are not yet considered standard medical care. Continuing clinical trials are needed to further improve the success rate of islet transplantation.
What is exciting is that the outcomes of islet transplant clinical trials keep significantly improving over the years. For some patients, islet transplant can restore the role of the pancreas. Unlike a pancreas transplant, islet transplant does not require major surgery.
The islet transplant procedure requires only a local anesthetic and takes about 60 minutes. The islets are injected into the liver where they secrete insulin directly into the circulatory system to control blood glucose.
For more information about the islet transplant clinical study visit the Schulze Diabetes Institute Web site.
Doctors & Providers
|Melena Bellin, MD|
|Sees Patients At:|
Pediatric Specialty Care Discovery Clinic
|James Harmon, Jr, MD|
Critical Care Surgeon, General Surgeon
|Sees Patients At:|
Surgery Clinic - East Bank
|Louise Berry, RN|
612-625-5115 or 800-328-5465
|Janet Bricher, RN|
|Sandra White, RN|
Locations by city:
Phillips-Wangensteen Building Second Floor, Clinic 2A 516 Delaware St. SE
Minneapolis, MN 55455