Overweight and obese people have an increased risk for diabetes, heart disease, stroke, hypertension, osteoarthritis, sleep apnea, and some forms of cancer. Obesity is also associated with menstrual irregularities, stress incontinence as well as psychological disorders such as depression. You also may be at risk for joint and bone problems. While there are no magic answers, the Weight Loss Center at University of Minnesota Medical Center, Fairview offers new hope for permanent weight loss.